In 1872, William Ponsot bought a domaine in Morey-Saint-Denis. Since then, several generations have followed and the vineyard has grown. Hippolyte began bottling at the domaine in 1932 and exporting to the United States in 1934. His son Jean-Marie was among the pioneers of clonal selection in Burgundy in the early 1960s. In 1972, his wife Jacqueline inherited several parcels of Gevrey-Chambertin and Chapelle-Chambertin. Today the heritage remains exclusively with the family, and the different parts of the domaine are held by Jean-Marie and Jacqueline Ponsot's children who continue to produce wines outside the fashionable phenomena. The domaine harvests very late, fully respecting traditional winemaking methods, without new wood or any filtration operation, resulting in spectacularly rich wines. In early 2017, Laurent Ponsot, who had run the domaine for many years, left the domaine (for personal reasons) and it is now his sister Rose-Marie Ponsot who has taken over.

Grand Cru Clos Saint-Denis is located in the town of Morey-Saint-Denis. This Grand Cru is often nicknamed "the Mozart of the Côte de Nuits" because of its supreme complexity. Clos Saint-Denis Grand Cru "Très vieilles vignes" is delicate, complex and lingers well on the palate, it is an excellent wine for aging. It comes from vines which are over 100 years old planted in clayey-limestone soil.