The name of this property is taken from two former owners: Malescot and Saint Exupéry, the grandfather of the famous aviator-writer. Château Malescot Saint Exupéry adjoins part of Château Margaux's vineyard. The soil in the vineyard consists of Pyrenean gravel. After a period of producing relatively disappointing wines between 1960 and 1980, the current owners focused their efforts on improving quality. From the beginning of the 1990s, the wines, with aromas of red fruit, have become richer and more intense, and have been more consistent. They are also now refined, offering a more delicate body.

The Dame de Malescot is Château Malescot Saint-Exupéry's second wine.